血清热休克蛋白70与妊娠的相关性研究

A related study of serum heat shock protein 70 and gestation

目的探讨妊娠期间母体与血清热休克蛋白之间的关系。方法用双抗体夹心ELISA法检测114例孕妇血清热休克蛋白含量,按孕3、5、7、8个月和足月共分五组,与非孕对照组比较。结果孕3-8个月组血清HSP70蛋白的含量与非孕对照组比较无差异(P>0.05),足月孕妇组血清HSP70含量明显升高,与非孕对照组比较有非常显著性差异(P<0.001);重度妊高征患者血清热休克蛋白70含量明显高于同孕龄正常孕妇组(P<0.001)。结论了解不同孕月健康孕妇血清HSP70含量,可为妊娠期间某些疾病引起的血清HSP70升高,提供参考依据。

Objective： The study attempts to see the relation between mother nuclide and serum heat shock protein during gesta- tional period. Methods： The contents of serum heat shock protein of 114 pregnant women have been tested with the double -antibody solid - phase technique ELISA. Five groups are divided ： 3 - month, 5 - month, 7 - month, 8 - month and full term. The results are compared with that of the non - pregnant group. Findings ： No difference has been found in the content of the serum HSP70 protein in 3 - 8 month groups （ P 〉 0. 05 ） ; There is a sharp rise in the content of the serum HSP70 protein in the full term pregnant group. Clear distinctness exists compared with the non - pregnant group （ P 〈0. 001 ） ; The content of the serum HSP70 protein of the patients with the severe pregnancy - induced hypertension syndrome is much higher than that of the normal pregnant group of the same gestational age. Conclusion： The content of the serum HSP70 protein of different gestational ages can provide reliable basis for some diseases causing the rise of serum HSP70 during gestational period.