皮下埋藏式灌注器腹腔化疗治疗中晚期消化道癌的临床观察

Intraperitoneal chemotherapy for advanced gastrointestinal malignancies with a totally implanted infusion pump

目的：探讨皮下埋藏式灌注器腹腔化疗治疗消化道恶性肿瘤的疗效。方法：将皮下埋藏式灌注器埋藏于腹壁下，其导管置于恶性肿瘤侵犯区内，于术后１～２周行灌注药物（５－ＦＵ、丝裂霉素），腹腔化疗６～９个疗程。结果：３１例消化道恶性肿瘤患者化疗后近期疗效显著。经ＣＴ、Ｂ超、ＧＩ检查随访１ａ，１７例（５４．８％）患者的恶性肿瘤阴影变小，８０．６％患者健康状态稳定。

Objective:To probe into the effects of a totally implanted infusion pump on gastrointestinal malignancies. Methods:31 patients confirmed pathologically with gastrointestinal malignancies were studied. The infusion pump was implanted into the abdominal wall and a plastic tube joining the pump was inserted into the tumorous area. Approximately 1～2 weeks after operation,5 Fluorouracil(5 FU) 1 gram diluted in Ringer's solution was weekly perfused into the patient's abdominal cavity through the tube. Mitomycin 10mg was added at the fourth week. After one month the intermited chemotherapy was repeatedly given for 6～9 courses. Results: During one year's CT,BUS and GI follow up check the health condition was steady in 80.6% patients and the tumorous shadows became smaller in 54.8% patients.Conclusion: The postoperative chemotherapy with a totally implanted infusion pump for advanced gastrointestinal malignancies can obtain favorable curative effect.