血液灌流时机与中间综合征预后的相关性分析

THE ANALYSIS OF THE CORRELATION BETWEEN THE TIMING OF HEMOPERFUSION AND THE PROGNOSIS OF INTERMEDIATE SYNDROME

目的:探讨血液灌流时机与急性有机磷农药中毒中间综合征预后的关系。方法:40例重度急性有机磷农药中毒中间综合征患者血液灌流时分为两组,中毒后24h内行血液灌流20例为治疗组,24h以后行血液灌流20例为对照组,通过观察阿托品用量、脱机时间及死亡率等指标判断疗效。结果:治疗组阿托品用量、脱机时间均低于对照组(P<0.01);治疗组死亡率15%,比对照组明显降低(P<0.01)。结论:早期血液灌流能清除体内有机磷农药,配合常规治疗可提高中间综合征抢救成功率。

Objective：To investigate the correlation between the timing of hemoperfusion（HP） and the prognosis of intermediate syndrome（IMS） caused by acute organic phosphorus poisoning（AOPP）. Methods：40 AOPP patients with IMS were divided into two groups randomly： treatment group（ HP within 24h） and contrast group （ HP after 24h）.The efficiency of treatment was evaluated through the total dose of atropine, the time of mechanical ventilation and mortality rate .Results：The total dose of atropine and the time of mechanical ventilation in the treatment group were lower than those of the contrast one （P〈0.01）. The mortality rate of treatment group （15%）is remarkably decreased compared with that of the contrast one （P〈0.01）. Conclusions：It is suggested that early HP associated with regular treatment can cleur the organic phosphorus from body,thus increase the rescue rate of IMS.