更昔洛韦在SDBS胶束中的电化学行为及其电化学测定方法

Electrochemical Behavior of Ganciclovir in the Presence of SDBS Micelles and Its Electrochemical Determination

以碳糊电极（CPE）为工作电极，在BR（Britton-Robinson Buffer）中用循环伏安法研究了更昔洛韦（GCV）在十二烷基苯磺酸钠（SDBS）胶束体系中的电化学行为，并以此建立了一种GCV电化学定量分析方法．用差分脉冲伏安法（DPV），在优化的测试条件下测得GCV氧化峰电流与其浓度在2．0×10^-7～2．0×10^-4mol／L范围内呈良好的线性关系，检出限为2．8×10^-8mol／L．该方法灵敏准确，用于GCV含量测定，结果令人满意．

Electrochemical behaviors of Ganciclovir （GCV） in sodium dodecyl benzene sulfonate （SDBS） have been studied by cyclic voltammetry. A sensitive method for the determination of GCV was proposed on the basis of the electrochemical response of GCV at a carbon paste electrode（CPE）. Under the optimal working conditions, the oxidation peak current of GCV versus its concentration has a good linear relationship in the range of 2.0×10^-7 - 2.0×10^-4 mol/L with the detection limit of 2.8×10^-8 mol/L by differential pulse voltammetry （DPV）. The proposed method can be applied to electrochemical determination of GCV with low detection limit, high sensitivity and satisfactory results.