钼对家兔亚硝酸钠中毒红细胞高铁血红蛋白还原的影响

Effect and its mechanism of molybdenum on reduction of methemoglobin in rabbit erythrocytes induced by sodium nitrite poisoning

通过用亚硝酸钠处理家兔红细胞，研究钼酸钠对高铁血红蛋白还原的影响及机制。结果显示钼可加速亚硝酸钠中毒高铁血红蛋白的还原，其主要在于钼能诱导红细胞维生素Ｃ的合成并促进其氧化，同时与钼能提高亚硝酸钠中毒红细胞抗氧化能力。

Effect and its mechanism of molybdenum on reductive rate of methemogolobin induced by sodium nitrite (NaNO_2) poisoning in rabbit erythrocytes were studied in vitro.It was found that molybdenum (0.1mmol/L as Na2MoO4) accelerated the reduction of methemoglobin induced by NaNO2.Further experiment showed that molybdenum promoted the synthesis and oxidation of vitamin C and kept the activity of NADHcytochrom b5 methemoglobin reductase by increasing the ability of antioxidation in rabbit erythrocytes. 