膀胱癌中Survivin的表达及临床意义

Expression of Survivin Gene and Its Clinical Implications in Bladder Cancer

目的:探讨Survivin基因在膀胱癌组织中的表达及临床意义。方法:采用Western-blot方法检测50例膀胱癌组织和22例正常膀胱黏膜中Survivin蛋白的表达。结果:Survivin蛋白在50例膀胱癌中阳性表达率为(81.0%),在22例正常膀胱黏膜中均无表达。在浸润性膀胱癌中(96.3%)较浅表性膀胱癌中(65.2%)显著升高(P<0.01);在复发性膀胱癌中(93.3%)较初发膀胱癌中(65.0%)显著升高(P<0.05)。结论:Survivin基因在膀胱癌组织中的表达量远远高于正常膀胱组织,其表达量还可用来预测膀胱癌的复发和浸润。

Objective：To investigate the expression of survivin protein in bladder cancer and it＇s clinical implica- tions. Methods ：Expression of survivin protein was detected by western blot in 50 bladder cancer tissues and in 22 normal mucosa of bladder. Results ：The total rate of survivin protein expression in 50 bladder cancer tissues was （81.0%）. Sur- vivin protein was not detected in 22 normal mucosa of bladder. The expression rate of survivin protein in infiltrated tu- mor （96.3% ） was significantly higher than that in superficial bladder cancers （65.2 %）（P〈0.01）, and the expression rate of survivin protein in relapsed tumors （93.3 %）was much higher than that in initial bladder cancers （65.0%）（P〈 0.05）. Conclutions ：The expression of survivin protein in bladder cancer tissues is mostly higher than it in normal mu- cosa of bladder,and the expression of survivin protein can serve as an indicator to predict recurrence and infiltration in bladder cancer.