便携式拉曼光谱仪用于磺胺类药物成分识别的研究

Study on identification of the constituents of sulfonamide drugs by the portable Raman spectrometer

目的:研究便携式拉曼光谱仪对磺胺类药物成分的识别能力。方法:使用TruScan便携式拉曼光谱仪,建立对照品图谱库,并测定磺胺类药物的拉曼光谱,通过图谱比对进行识别。结果:该类药物各成分对照品图谱峰形良好,特征性强,可准确区分;利用对照谱库可准确识别制剂中主成分。结论:便携式拉曼光谱仪具有快速、简便、准确率高、无损测量及识别自动化等优点,有望成为药品日常监督中一种有效的鉴别手段。

Objective：To investigate the capability of the portable Raman spectrometer for the identification of constituent of the sulfonamide drugs.Methods：The TruScan handheld Raman spectrometer was uesd to establish the standard spectrum library,and identify constituents of the sulfonamide drugs.Results：The peak of the standard spectrum was well and characteristic.It was shown that the principal constituent of the preparation tested were exactly identified.Conclusion：The system is fast,simple,accurate,with automated identification and no sample damage,so it may be an effective identification means in daily inspection in the future.