2型糖尿病患者龈沟液中肿瘤坏死因子α的含量及其临床意义

TNF-α level in gingival crevicular fluid and its clinical significance in T2DM patients

目的比较T2DM患者与健康人龈沟液(GCF)及其中肿瘤坏死因子α(TNF-α)含量,以及TNF-α与精代谢的关系,探讨T2DM患者易患牙周病原因。方法用滤纸条法采集30例T2DM患者(DM组)和30例正常健康者(NC组)的GCF,测定其TNF-α含量;测定DM组HbA_1c水平。结果DM组GCF中TNF-α含量和GCF量均显著高于NC组,TNF-α与GCF量之间有显著的直线相关性。DM组GCF中TNF-α含量与HbA_1c水平无显著直线相关性。结论糖尿病患者龈沟液量和龈沟液TNF-α水平显著升高,导致易患牙周病。

Objective To compare the TNF-α level in gingival crevicular fluid（GCF） between type 2 diabetics with periodontal diseases and systemically healthy person. Methods Thirty diabetic patients and thirty systemically healthy persons were included in this study. Their TNF-α was measured by radioimmunoassay, and HbA1c by high-performance liquid chromatography. Results Diabetics had higher TNF-α level and the more quantity of GCF as compared to the control group（P〈0. 01）. The levels of TNF-α of diabetics did not correlate with HbA1c levels（P〉0. 05）. Conclusions The fluid amount and TNF-α level of gingival crevicular fluid are increased in T2DM, which may he associated with periodontal disease.