长期补碘后甲状腺疾病的变迁

The variation of thyroid disease after long term iodine supplement.

为探讨人工补碘后引起的甲状腺疾病发生率与构成比的改变，回顾３４年间手术切除的甲状腺标本６０００例，并对部分标本采用流式细胞仪（ＦＣＭ）检测细胞核ＤＮＡ含量及倍体分型。结果：甲状腺癌由３１％升至１６１０％，其中乳头状癌所占比例以每１０年增加５％的速度由４２５％增至５８６０％；女性甲状腺癌的发病年龄明显年轻化。ＦＣＭ发现：甲状腺良性疾病异倍体率高达１５％～１８％。由此推测，在长期补碘的缺碘地区，缺碘性甲状腺肿存在恶变问题，可能成为该地区甲状腺癌的主要原因之一。

The article retrospect about six thousand thyroid specimens that was exsected in our hospital during thirty four years Content of DNA of cell nuclear and chromosomal ploidy were estimaed by flow cytometry (FCM) inpart of these specimens result manifest incidence rate of thyroid cancer rise from 3 1 percent to 10 4 percant Ratio of papillary cancer raise 5 percent every decade from 42 5 parcent to 58 6 percent The incidence age of female patient is younger and younger By flow cytometry,We find aneuploid rate rise up to 15-18 percent In benign thyroid disease Therefore,We speculate that canceration of iodine deficienly goiter in iodine deficienly district where diet is added iodine for long time is one of important aygnt of throid cancer