兔动脉硬化时红细胞膜及血清唾液酸含量的改变

The changes of the sialic acid contents of erythrocyte membrane and serum in the rabbits with atherosclerosis

目的：探讨红细胞膜及血清唾液酸含量与动脉粥样硬化（ＡＳ）的相关性。方法和结果：用食饵性高血脂及食饵性高血脂加免疫性动脉内皮损伤的方法建立兔ＡＳ模型，观察到随着ＡＳ的发生，红细胞膜唾液酸含量降低，而血清唾液酸含量增高，与对照组比较均有显著差异（Ｐ＜０．０５，Ｐ＜０．０１）。ＡＳ的程度与红细胞膜的唾液酸含量呈显著负相关（ｒ＝－０．８３７，Ｐ＜０．０１），而与血清唾液酸含量呈显著正相关（ｒ＝－０．８０４，Ｐ＜０．０１）。红细胞膜唾液酸的含量与血清唾液酸的含量呈显著负相关（ｒ＝－０．８２０，Ｐ＜０．０１）。

Objective: To examine the relationship between the sialic acid contents of erythrocyte membrane and serum with the atherosclerosis in rabbits. Methods and Results: The model of experimental atherosclerosis was established in rabbits by means of cholesterolfed or cholesterolfed combined with immunopathologic endothelial injuries, respectively. The sialic acid contents of erythrocyte membrane and serum were measured, and the relationship of the sialic acid contents of erythrocyte membrane and serum with the atherosclerosis was evaluated by means of linear correlationship and regression methods. In the rabbits with atherosclerosis, the contents of sialic acid of erythrocyte membrane was significantly decreased and significant negative correlation was shown as compared with the degree of atherosclerosis (r=-0.837, P<0.01), but that of serum was significantly increased and significant positive correlation was shown as compared with the degree of atherosclerosis (r=-0.804, P<0.01). Significant negative correlation was shown between the sialic acid contents of erythrocyte membrane and serum (r=-0.820, P<0.01). Conclusion: Sialic acid concentrations of erythrocyte and serum probably have a close relationship with the formation or the severity of atherosclerosis.