依那普利治疗慢性心衰的耐受性研究

Studay on Drug Tolerance of Enalapril on Chronic Heart Failure

目的:对慢性心衰患者,观察将依那普利5mg/d调整至20mg/d后的耐受性。方法:入组已服用依那普利5mg/d至少4周的慢性心衰患者,采用依那普利20mg/d治疗2个月,观察增量以后的安全性与耐受性。观察指标:不良事件和严重不良事件,患者依从性,记录基线状态、第4周、第8周血压、心率、血钾、肌酐和尿素氮。结果:共入选89例符合入选标准的慢性心衰患者,其中83例能够很好耐受依那普利,总耐受率为93.3%。共计13例患者(占14.6%)发生不良事件,无严重不良事件发生。结论:慢性心衰患者对依那普利20mg/d的治疗剂量耐受良好。

Objective： To evaluate the tolerability of enalapril dose- adjustment 5mg/d to 20mg/d in the patients with congestive heart failure. Method：Chosen patients with congestive heart failure who had received enalapril 5mg/d for at least 4 weeks, then given them enalapril 20mg/d for 2 months and observed the patients＇ safety and tolerability after the dose or enalapril had been increased to 20mg/d. Adverse events, blood pressure, heart rate, K ＋, Cr , BUN at baseline, week 4 and week 8 were recorded. Result： A total of 89 patients with congestive heart failure were included in the study, enalapril was well tolerated in 83 patients （ 93.3% ）. 13 out of 89 （ 14.6% ） patients experienced mild adverse events during observation period. No serious event was recorded. Conclusion： Enalapril 20mg/d can be well tolerated by patients with chronic heart failure.