上海地区人群葡萄糖-6-磷酸脱氢酶活力测定

Determination of G6 PD activity in Shanghai

目的 :了解上海地区人群葡萄糖 - 6-磷酸脱氢酶 ( G6PD)活力水平及 G6PD缺乏的发生情况 ,观察 G6PD与糖尿病之间可能存在的关系。方法 :采用标准方法测定该地区随机人群 555例及糖尿病患者 169例 G6PD活力。结果 :G6PD活力在随机人群为 5.4 1± 1.2 6U / g Hb-1,糖尿病患者中为 4 .81±1.30 U/ g Hb。结论 :糖尿病患者的 G6PD较随机人群显著降低 ( P<0 .0 1) ,G6PD缺乏的发生率随机人群为 1.4 4 % ,糖尿病患者为 3.55% 。

Objective:To investigate the G6 PD activity and the incidence of G6 PD deficiency in Shanghai region,and to elucidate the relationship between G6 PD activity and diabetes mellitus.Methods:A total of 5 5 5 randomly selected in- dividials (2 97males,2 5 8females as control) and 16 9patients with diabetes mellitus (90 males,79females) were exam- ined.Results:The levels were5 .41± 1.2 6 U/ g Hb and4.81± 1.30 U/ g Hb,respectively,a statistically significantdiffer- ence on G6 PD activity was observed(P<0 .0 1) .Conclusinos:Further analysis showed that the incidence of G6 PD defi- ciency in these two groups was.1.44 % among controls and3.5 5 % in patients with diabetes mellitus,no statistical sig- nificance was observed in this study