交感神经皮肤反应在检测2型糖尿病患者自主神经损害中的价值

Investigation of sympathetic skin response in 81 patients with type 2 diabetes mellitus

目的探讨交感神经皮肤反应(SSR)检测在评价2型糖尿病(T2DM)自主神经损害中的价值。方法对81例T2DM患者进行SSR检测,30例健康志愿者作为对照。结果①两组SSR的起始潜伏期及波幅比较差异有统计学意义(P<0.05)。T2DM组69例(85.1%)患者至少有一肢SSR异常;②与血糖控制满意组比较,血糖控制不良组的下肢起始潜伏期延长(P<0.05),下肢波幅降低(P<0.05),而上肢的起始潜伏期及波幅的差异无统计学意义(P>0.05);③T2DM组病程<5年与病程≥5年比较,起始潜伏期及波幅差异均无统计学意义(P>0.05)。结论SSR可作为评价T2DM自主神经损害的客观电生理指标;T2DM患者SSR与血糖控制水平相关,与病程无关。

Objective To investigate the significance of sympathetic skin response （SSR） to automatic dysfunction in patients with type 2 diabetes mellitus （T2DM）. Methods SSR was carried out in 81 patients with T2DM and in 30 age - and gender - matched healthy volunteers at the same time. Results There were significant difference of the onset latencies and peak amplitudes of SSR between two groups（P 〈0.05 ）. 85.1% of patients with T2DM showed abnormal SSR at least one limb. The SSR onset latencies of the lower limbs were prolonged significantly in poorly glyeemic controlled group as compared to adequately glycemic controlled group, the SSR peak amplitudes of the lower limbs were reduced significantly in poorly glycemic controlled group as compared to adequately glycemic controlled group, while there was on significant difference in the SSR onset latencies and peak amplitudes of the upper limbs. There was no significant difference of the SSR onset latencies and peak amplitudes in two groups （ diabetes duration more than 5 years or diabetes duration less than 5 years）. Conclusion SSR is an objective electro - physiological method to assess the autonomic dysfunction related to DM. The abnormal SSR is significantly correlated to the blood glucose, but not to diabetes duration.