原发性高血压患者动态脉压与左心室肥厚相关性研究

Relationship between ambulatory pulse pressure and left ventricular hypertrophy in essential hypertension

目的探讨原发性高血压患者动态脉压和左心室肥厚之间的相关性。方法根据超声心动图检查结果,按左心室心肌质量指数(LVMI)男>120g/m2,女>115g/m2,将242例高血压患者分为左心室肥厚组(64例)和非左心室肥厚组(178例),并进行24h动态血压监测。结果左心室肥厚组的24h平均脉压(PP)、白天脉压(dPP)、夜间脉压(nPP)和非左心室肥厚组相比差异有统计学意义(P<0.05)。直线相关分析结果显示LVMI与年龄、SBP、PP显著相关(P<0.01)。多元回归分析结果显示,PP是LVMI的主要影响因素(P<0.01)。结论PP增大与高血压患者LVH密切相关,是LVMI的主要影响因素。

Objective To explore the relationship between ambulatory pulse pressure and left ventricular hypertension in essential hypertension. Methods Echocardiography were performed, according to their left ventricular mass index （LVMI） , 242 patients with essential hypertension were divided into two groups ： LVH group （ LVMI 〉 120g/m^2 in man, and 〉 115g/m^2 in woman, n = 64） and non - LVH group （ n = 178 ） , all patients were monitored 24 - hour ambulatory blood pressure. Results LVH group showed higher levels of 24 - hour pulse pressure, day time pulse pressure, night time pulse pressure than those in non - LVH group （ P 〈 0.05）. In linear correlation analysis, age, SBP, PP was positive correlation with LVMI （ P 〈 0.05 ）. Multiple stepwise regression analysis showed that the changes in average levels of 24 - hour pulse pressure were important influence factor to LVMI （ P 〈 0.01 ）. Conclusion The higher levels of 24 - hour pulse pressure are close correlation with LVH and especially important influence factor to LVH in patients with essential hypertension.