复方茵虎汤对实验性肝损伤的保护作用

Protective effect of compound Yinhu decoction on experimental liver injury

目的:本实验研究复方茵虎汤(复方茵虎汤)对四氯化碳致小鼠肝损伤的保护作用。方法:以腹腔注射四氯化碳(CCl4)建立小鼠肝损伤模型,以复方茵虎汤作为受试药物,以联苯双酯作为阳性对照药物,以肝指数(LI)、血清中谷氨酸氨基转移酶(ALT)、天冬氨酸转氨酶(AST)、肝组织匀浆中超氧化物歧化酶(SOD)和丙二醛(MDA)水平为检测指标,观察复方茵虎汤对肝损伤的保护作用。结果:复方茵虎汤能够明显降低CCl4致小鼠肝损伤血清中ALT和AST水平,升高肝组织中SOD水平,降低肝组织中MDA水平,减轻四氯化碳对肝脏细胞的病理损伤。结论:复方茵虎汤对CCl4致小鼠急性肝损伤有一定的保护作用。

Objective： To observe the protective effect of Compound Yinhu decoetion on acute liver injury induced by carbon tetraehloride （ CCl4 ） in mice. Methods ： Acute liver injury was established by intraperitoneal injection of CCl4. Compound Yinhu deeotion was tested as subjeels drug and bifendate as a positive control drug. The liver index （L1）, the levels of serum alanine amino-transferase （ALT） and aspatate anino-transferase （AST）, the superoxide dismutase （SOD） and molondialdehyde （MDA） levels in the liver tissue were measured and the prolective effect of Compound Yinhu deeotion on liver injury was observed. Results：Compound Yinhu deeotion eonld signifieantly reduee serum AIX and AST levels, inerease liver SOD level and decrease liver MDA level. It eould also reduce the liver cell morphological injurary. Conclusions：Compound Yinhu decotion has some protective effeet on acute liver injury induced by CCl4 in mice.