期刊文献+

地特胰岛素减少体重增加机制浅析

下载PDF
导出
摘要 1922年Banting成功提纯胰岛素至今已八十多年。胰岛素挽救了众多糖尿病患者的生命。诸多大型临床试验也相继证实了胰岛素强化治疗的益处,千百万糖尿病患者受益于外源性胰岛素治疗。但不可否认,由于无法修复和重现机体生理状态下胰岛素介导的血糖平衡,胰岛素治疗也存在着一些问题,其中最突出的是低血糖和体重增加。
作者 关美萍 沈洁
出处 《药品评价》 CAS 2009年第4期161-164,共4页 Drug Evaluation
  • 相关文献

参考文献7

  • 1A. M. Hennige,T. Sartorius,O. Tschritter,H. Preissl,A. Fritsche,P. Ruth,H.-U. H?ring.Tissue selectivity of insulin detemir action in vivo[J].Diabetologia.2006(6)
  • 2S. V. M. Hordern,J. E. Wright,A. M. Umpleby,F. Shojaee-Moradie,J. Amiss,D. L. Russell-Jones.Comparison of the effects on glucose and lipid metabolism of equipotent doses of insulin detemir and NPH insulin with a 16-h euglycaemic clamp[J].Diabetologia.2005(3)
  • 3Bohm A,,Staiger H,Hennige AM,et al.Effect of insulin detemir,compared to human insulin,on 3T3-L1 adipogenesis[].Regulatory Peptides.2008
  • 4.Effect of intensive diabetes management on macrovascular events and risk factors in the Diabetes Control and Complications Trial[].The American Journal of Cardiology.1995
  • 5A. Dornhorst,H.J. Lüddeke,C. Koenen.Transferring to insulin detemir from NPH insulin or insulin glargine in type 2 diabetes patients on basalonly therapy with oral antidiabetic drugs improves glycaemic control and reduces weight gain and risk of hypoglycaemia: 14-week follow-up data from PR[].Diabetes Obesity and Metabolism.2008
  • 6Kurtzhals P.Engineering predictability and protraction in a basal insulin analogue:the pharmacology of insulin detemir[].International Journal of Obesity and Related Metabolic Disorders.2004
  • 7Davies MJ,Derezinski T,Pedersen CB,et al.Reduced weight gain with insulin detemir compared to NPHinsulin is not explained by a reduction in hypoglycemia[].Diabetes Technology and Therapeutics.2008

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部