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氡染毒小鼠肺组织let-7a表达的初步研究 被引量：2

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摘要 氡在衰变过程中，产生的氡子体，既有α辐射，也有β和γ辐射，其中α辐射最为重要。氡及子体已成为仅次于吸烟的第二大肺癌相关的环境和职业致癌因子。人类肺癌的10％左右可归因于氡及其子体的辐射。MicroRNA是一类长约18～24nt的非编码RNA分子。MicroRNA普遍存在于生物界，具有高度的保守性，广泛参与细胞分化与发育、细胞凋亡、肿瘤发生等多方面的基因表达调控。
作者 高刚 田梅 杨英杰 刘建香 苏旭
机构地区 中国疾病预防控制中心辐射防护与核安全医学所
出处 《中华放射医学与防护杂志》 CAS CSCD 北大核心 2009年第2期204-205,共2页 Chinese Journal of Radiological Medicine and Protection
关键词 氡子体 染毒小鼠 MicroRNA 肺组织 基因表达调控 RNA分子 α辐射 致癌因子
分类号 R114 [医药卫生—卫生毒理学]
  • 相关文献

参考文献11

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二级参考文献26

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共引文献30

同被引文献22

  • 1潘自强,修炳林.“联合国原子辐射效应科学委员会第54次会议”情况介绍[J].辐射防护,2006,26(4):254-256. 被引量：4
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  • 4Yamanka K, Mitsunobu F, Kujima S, et al. The elevation of p53 protein level and SOD activity in the resident blood of the Misasa radon hot spring district. J Radiat Res.2005.46( 1):21-24.
  • 5Raver-Shapira N, Marciano E, Meiri E, et al. Transcriptional activation of miR-34a contributes to p53-mediated apoptosis. Mol Cell,2007,26 (5) : 731-743.
  • 6Bommer GT, Gerin I, Feng Y, et al. p53-mediated activation of miRNA34 candidate tumor-suppressor genes. Curr Biol, 2007,17 ( 15 ) :1298-1307.
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  • 8Johnson SM, Grosshans H, Shingara J, et al. RAS is regulated by the let-7 microRNA family. Ce11,2005,120(5) :635-647.
  • 9Inamura K, Togashi Y, Nomura K, et al. let- 7 microRNA expression is reduced in bronchioloalveo|ar carcinoma, a non- invasive carcinoma, and is not correlated with prognosis. Lung Cancer,2007,58 ( 3 ) :392-396.
  • 10耿继武,苏世标,温翠菊,谭惠玲,陈建雄,邹剑明.阳江天然高本底辐射地区居民外周血P53蛋白表达的研究[J].中国职业医学,2007,34(6):453-455. 被引量：2

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二级引证文献7

中华放射医学与防护杂志
2009年 第2期

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