扩散张量成像观察先天性耳聋患者脑白质结构

Diffusion tensor imaging observation of brain white matter in congenitally deaf

目的利用扩散张量成像(DTI)研究先天性耳聋(CD)患者的脑白质结构,探讨脑白质变化机制。方法对6名先天性耳聋患者和6名正常人进行脑部DTI扫描,应用基于体素的分析(VBA)对CD组和正常对照(HC)组的全脑分数各向异性(FA)值进行比较,计算样本感兴趣区(ROI)Brodmann(BA)41、BA22和BA44区的平均FA值。结果CD组FA值显著减少的区域位于右脑的颞上回(STG),ROI平均FA值除在右脑BA22区有下降的趋势外,未发现显著异常;CD组和HC组中左脑ROI的平均FA值显著偏大。结论先天性耳聋患者右脑STG白质损伤,这种结构异常是由其先天缺乏声音刺激所造成的。

Objective To investigate structure of brain white matter in patients with congenitally deaf （CD） with diffusion tensor imaging （DTI）, and to probe into the mechanism of CD brain white matter alteration. Methods Fractional anisotropy （FA） of 6 cases of CD and 6 healthy controls （HC） were compared with voxel-based analysis （VBA） in a whole brain manner. Average FA value in Brodmann （BA） 41, 22 and 44 areas of all participators were calculated for statistical analysis. Resuits Significant FA value decrease was found in CD located in white matter tissue of superior temporal gyrus （STG） in the right hemisphere. No statistical significant difference was found from the two-samples t-test of average FA value in region of interesting （ROD, except that a lower tendency was inspected in BA22 of right hemisphere in CD. Furthermore, leftward asymmetry of FA value was found in both CD and HC. Conclusion White matter integrity damage happens in right auditory association region of CD, which may be corresponding to the lack of auditory input since birth.