摘要
转化生长因子β(transforming growth factorbeta,TGF-β)是一种对细胞生长、分化和多种生理、病理过程起重要调节作用的细胞因子.TGF-β-Smad信号通路是肿瘤发生机制中的重要通路,Smad4在TGF-β-Smad通路中处于核心地位.近来大量研究发现,Smad4在肿瘤的侵袭和转移过程中发挥重要作用,本文就此予以综述.
Transforming growth factor beta (TGF-β) is a ubiquitous and essential regulator of cellular and physiologic processes including proliferation, differentiation, migration, cell survival, an- giogenesis and immunosurveillance. The tumor suppressor gene Smad4 (DPC4) is the central intracellular mediator of transforming growth factor-β-Smad(TGF-β-Smad) signaling, which is a key pathway in cancer invasion and metastasis. This review focuses on the mechanisms whereby the Smads are modified and regulated,I and summarizes current views on the role of Smad4 in tumorigenesis, with emphasis on can-I cer invasion and metastasis.
出处
《世界华人消化杂志》
CAS
北大核心
2009年第9期849-853,共5页
World Chinese Journal of Digestology
基金
江苏省自然科学基金资助项目
No.BK2001168
南京市科技发展基金资助项目
No.20080128
南京医科大学科技发展基金重点资助项目
No.CX2004029
南京医科大学科技发展基金重点资助项目
No.08NMUZ021~~