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ATP敏感性钾通道及其心血管保护作用 被引量：4

ATP-sensitive potassium channel and its cardiovascular protection effects
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摘要 ATP-sensitive potassium channel(KATP) consists of a 4.4 complex of an inwardly rectifying Kir6.x pore plus a sulfonylurea receptor,which is an ATP-binding cassette transporter.KATP has been indentified in a variety of tissues and recognized as an important drug target.It connects cell metabolism with cell electric activity.KATP has been proposed to play protective roles during heart failure,arrhythmia,myocardial infarction,stress,myocardial ischemia and hypertension.In this review,a summary of KATP is presented with molecular structure,localization,regulation,cardiovascular protective effect and its mechanisms. SUMMARY ATP-sensitive potassium channel（ KATP ） consists of a 4. 4 complex of an inwardly rectifying Kir6. x pore plus a sulfonylurea receptor, which is an ATP-binding cassette transporter. KATP has been indentified in a variety of tissues and recognized as an important drug target. It connects cell metabolism with cell electric activity. KATP has been proposed to play protective roles during heart failure, arrhythmia, myocardial infarction, stress, myocardial ischemia and hypertension. In this review, a summary of KATP is presented with molecular structure, localization, regulation, cardiovascular protective effect and its mechanisms.
作者 张荣媛 金红芳 唐朝枢 杜军保
机构地区 北京大学第一医院儿科 北京大学基础医学院生理与病理生理学系 教育部分子心血管重点实验室
出处 《北京大学学报（医学版）》 CAS CSCD 北大核心 2009年第2期245-248,共4页 Journal of Peking University:Health Sciences
基金 国家重点基础研究发展规划项目基金(2006CB503807) 国家杰出青年科学基金(30425010)资助~~
关键词 钾通道 腺苷三磷酸 心血管系统 Potassium channels Adenosine triphosphate Cardiovascular system
分类号 R363.274 [医药卫生—病理学]
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参考文献25

  • 1Noma A. ATP-regulated K^+ channels in cardiac muscle [J]. Nature, 1983, 305 (5930) : 147 - 148.
  • 2Aguilar Bryan L, Clement JP IV, Gonzalez G, et al. Toward understanding the assembly and structure of KATP channels [ J ].Physiol Rev, 1998, 78( 1 ) : 227 -245.
  • 3Gnbble FM, Ashfield R, Ammala C, et al. Properties of cloned ATP sensitive K^+ currents expressed in xenopus oocytes [ J ]. J Physiol, 1997, g98(pt1) : 87 -98.
  • 4Tusnady GE, Bakos E, Varadi A, et al. Membrane topology distinguishes a subfamily of the ATP-binding cassette ( ABC ) transporters[J]. FEBS Lett, 1997, 402(1) : 1-9.
  • 5Donley VR, Hiskett EK, Kidder AC. ATP sensitive potassium channel ( KATp channel) expression in the normal canine pancreas and in canine insulinomas[ J]. BMC Vet Res, 2005, 1 (12) : 8 - 16.
  • 6Morrissey A, Rosner E, Lanning J. Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature[J]. BMC Physiology, 2005, 5(1) : 1 -9.
  • 7Pu JL, Ye B, Kroboth SL, et al. Cardiac sulfonylurea receptor short form-based channels confer a glibenelamide-insensitive KATP activity[J]. J Mol Cell Cardiol, 2008, 44(1 ) : 188 -200.
  • 8Reimann F, Ashcroft FM, Gribble FM. Structural basis for the inter ference between nicorandil and sulfonylurea action[J]. Diabetes, 2001, 50(10): 2253-2259.
  • 9Pel MR, Pah PA, Pen PS, et al. Analysis of single KATP Channels in mammalian dentate gyrus granule cells [ J ]. J Neurophysiol, 2000, 84(5): 2291 -2301.
  • 10Song DK, Ashcroft FM. Glimep iride block of cloned beta-cell, cardiac and smooth muscle KATe channels [J]]. Br J Pharmacol, 2001, 133(1): 193-199.

同被引文献63

  • 1司延斌,龚培力.尼可地尔对心肌肥厚模型大鼠的保护作用及机制研究[J].中国药房,2006,17(17):1294-1297. 被引量：3
  • 2段燕红,陈付学.ATP敏感钾通道的结构、功能及其调制[J].医学分子生物学杂志,2007,4(1):54-58. 被引量：5
  • 3Noma A.ATP-regulated K+ channels in cardiac muscle. Nature. 1983;305(5930): 147-148.
  • 4Nichols CG, Singh GK,Grange DK. KATP channels and cardiovascular disease: suddenly a syndrome. Circ Res. 2013 112(7): 1059-1072.
  • 5Clark R, Proks P. ATP-sensitive potassium channels in health and disease. Adv Exp Med Bio1.2010;654: 165-192.
  • 6Inoue I, Nagase H, Kishi K, et al.ATP-sensitive K+ channel in the mitochondrial inner membrane. Nature. 1991 ;352(6332): 244-247.
  • 7Rodrigo GC, Standen NB. ATP-sensitJve potassium channels. Curr Pharm Des.2005; 11 (15): 1915-1940.
  • 8Olson TM, Terzic A.Human K(ATP) channelopathies: diseases of metabolic homeostasis. Pflugers Arch. 2010;460 (2): 295-306.
  • 9Wang X, Wu J, Li L, et al. Hypercapnic acidosis activates KATP channels in vascular smooth muscles. Circ Res.2003; 92(11):1225-1132.
  • 10Aziz Q, Thomas AM, Gomes J, et al. The ATP-Sensitive Potassium Channel Subunit, Kir6.1, in Vascular Smooth Muscle Plays a Major Role in Blood Pressure Control. Hypertension. 2014 ;64(3):523-529.

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北京大学学报（医学版）
2009年 第2期

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