摘要
ATP-sensitive potassium channel(KATP) consists of a 4.4 complex of an inwardly rectifying Kir6.x pore plus a sulfonylurea receptor,which is an ATP-binding cassette transporter.KATP has been indentified in a variety of tissues and recognized as an important drug target.It connects cell metabolism with cell electric activity.KATP has been proposed to play protective roles during heart failure,arrhythmia,myocardial infarction,stress,myocardial ischemia and hypertension.In this review,a summary of KATP is presented with molecular structure,localization,regulation,cardiovascular protective effect and its mechanisms.
SUMMARY ATP-sensitive potassium channel( KATP ) consists of a 4. 4 complex of an inwardly rectifying Kir6. x pore plus a sulfonylurea receptor, which is an ATP-binding cassette transporter. KATP has been indentified in a variety of tissues and recognized as an important drug target. It connects cell metabolism with cell electric activity. KATP has been proposed to play protective roles during heart failure, arrhythmia, myocardial infarction, stress, myocardial ischemia and hypertension. In this review, a summary of KATP is presented with molecular structure, localization, regulation, cardiovascular protective effect and its mechanisms.
出处
《北京大学学报(医学版)》
CAS
CSCD
北大核心
2009年第2期245-248,共4页
Journal of Peking University:Health Sciences
基金
国家重点基础研究发展规划项目基金(2006CB503807)
国家杰出青年科学基金(30425010)资助~~
关键词
钾通道
腺苷三磷酸
心血管系统
Potassium channels
Adenosine triphosphate
Cardiovascular system