265例SLE患者合并感染的调查分析

AN INVESTIGATION OF 265 CASES OF SYSTEMIC LUPUS ERYTHEMATOSUS WITH CONCURRENT INFECTION

本文对265例SLE患者合并感染情况进行回顾性统计分析，结果显示，SLE患者感染率62．3％，医院感染率为21．9％，狼疮活动组和病情稳定组的感染率分别为68．3％和49．4％，有非常显著差异（P＜0．01）；老年组、成年组、小儿组的感染率分别为65％、62％和60％，差异无显著性（P＞0．05）。与感染相关因素包括基础病的严重程度；激素和免疫抑制剂、抗生素的使用；侵袭性操作；原发病误诊；住院时间太长。感染明显影响SLE患者的预后。

The 265 cases of systemic lupus erthe-matosus (SLE) were investigated The re-sults showed that infection rate was 62. 3%.of them, nosocomial infection rate was 21. 9%. The infection rates of the active SLE group and the stable SLE group were raspectively 68.3% and 49.4% and there was a significant difference (P<0.01). The infection rates of the aged group, the adult group and children group were 65%、62% and 60% respectively and there was no sig- nificant difference (P>0. 05). The factors causing the infection included the using of broad - spectrum antibotics, cordicos-teroids, immune inhibitors. the concurrent infection obviously affected the prognosis of the patients with SLE.