心肌缺血预适应对缩小老年心肌梗塞范围的临床研究

TX Clinical study on the limitation of infarct size by ischemic preconditioning in aged patients with AMI

目的探讨心肌缺血预适应对老年急性心肌梗塞（ＡＭＩ）患者梗塞面积的影响。方法对照分析心肌梗塞前６６例有心肌缺血预适应与４４例无心肌缺血预适应老年ＡＭＩ患者的临床资料。结果有心肌缺血预适应老年ＡＭＩ患者其肌酸磷酸激酶（ＣＰＫ）与肌酸磷酸激酶同功酶ＭＢ（ＣＫ－ＭＢ）峰值，复杂室性期前收缩、泵功能障碍发生率与近期死亡率等均显著低于无心肌缺血预适应老年ＡＭＩ患者（Ｐ＜０．０１与Ｐ＜０．０５）。结论心肌缺血预适应有缩小老年心肌梗塞面积的作用，故对其近期预后可产生有益的影响。

bjective The influence of ischemic preconditioning on the infarct size in aged patients with AMI was studied. Methods The clinical data of 66 elderly patients with ischemic preconditioning before AMI(group A)and 44 elderly patients suffering from AMI without ischemic preconditioning (group B) were comparatively analyzed. Results Peak levels of serum CPK and CPKMB,complex ventricular premature beats,incidence of cardiac pump function disturbance and shortterm mortality rate in group A were significantly lower than those in group B(P<001 or P<005). Conclusions Ischemic preconditioning can limit the infarct size,which may have good influence on the shortterm prognosis.