D-二聚体/FDP比值在急性与陈旧性脑梗死诊断中的意义

The significance of D-dimer/FDP ratio in distinguish acute and outmoded cerebral infarction

目的研究急性与陈旧性脑梗死时患者血浆凝血、纤溶活性的变化,探讨D-二聚体/FDP比值在急性与陈旧性脑梗死时的应用价值。方法比较40例急性脑死塞患者与40例陈旧性脑梗死患者血浆凝血、纤溶活性。检测血浆中的纤维蛋白原(Fbg)、D-二聚体(D-dimer)、纤维蛋白(原)降解产物(FDP)三个参数。对三个参数分别进行组合分析,评价不同组合在鉴别急性与陈旧性脑梗死时的应用价值。结果急性脑梗死组血浆D-二聚体/FDP比值明显高于陈旧性脑梗死组(P<0.05);而单独Fbg、FDP比较两组差别无显著性(P>0.05);两组单独D-dimer结果均与正常参考值有差别(P<0.05),但两组相比较,D-dimer值差别无显著性(P>0.05)。结论急性脑梗死的发生存在血液高凝状态大于纤溶状态,D-二聚体/FDP比值可以作为诊断急性与陈旧性脑梗死的快速简便实验室指标。

Objective To study the alteration of plasma coagulation and fibrinolation in acute and outmoded cerebral infarction patients, Discuss the value of D-dimer/FDP ratio in the distinguish diagnosis of acute and outmoded cerebral infarction. Methods To compare 40 acute cerebral infarction patients and 40 outmoded cerebral infarction Patients of coagulation and fibrinolytic activityctivities. To examine plasma Fbg, D-dimer and FDP and study the vary combination of them. Results D-dimer/FDP ratio in acute cerebral infarction group was significantly higher than that in outmoded cerebral infarction group（ P 〈 0.05）. The isolate levels of Fbg and FDP in acute and outmoded cerebral infarction groups have no signifacately changes （ P 〉 0.05 ）, both are higher than normal range （ P 〈 0.05）, But D-dimer and FDP levels have no signifacately changes between acute and outmoded cerebral infarction groups（ P 〉 0.05）. Conclusion It is higher coagulated activity than fibrinolytic activity when acute cerebral infarction Occurs, D-dimer/FDP ratio may be use as an rapid and simple distinguish factor in acute cerebral infarction recurrence.