原发性干燥综合征患者血清骨桥蛋白水平及其临床意义

Expression of serum OPN in primary sjogren's syndrome and clinical significance

目的探讨血清骨桥蛋白(OPN)在原发性干燥综合征患者中表达水平及其临床意义。方法采用ELISA法检测40例pSS患者与40例健康人血清OPN水平。结果pSS患者血清OPN水平(460±280)ng/ml显著高于正常对照组(68±10)ng/ml,P<0.01;血清OPN水平与RF呈正相关,(r=0.30,P=0.01);与Anti-SSA、Anti-SSB、C3、C4、ANA滴度无显著相关性(P>0.05)。结论pSS患者血清中OPN表达增高,且与RF呈正相关,OPN的异常表达可能是pSS发病的重要环节。

Objective To investigate the expression of serum osteopontin （OPN） in primary sjogren＇s syndrome （pSS） patients and the association with the clinical significance.Methods The serum concentration of OPN in pSS patients and healthy controls was measured with enzyme-linked immunosorbent assay. Results Significant higher OPN levels were detected in patients of pSS than that controlgroup （ P 〈 0.01 ）. The expression level of OPN showed positive correlations with RF （ r = 0.30, P = 0.01 ）. There was no correlation between OPN levels and serum concentration of Anti-SSA, Anti-SSA,ANA, C3 and CA in pSS patients（ P 〉 0.05）. Conclusion The serum OPN level was significantly elevated and correlates with the level of RF. These data indicated that OPN might play certain role in the pathogenesis and progress in pSS.