丝裂霉素、长春花碱酰胺、顺铂联合治疗非小细胞肺癌61例报告

A Report on the Combined Treatment of 61 Cases of Non-small Cell Lung Cancer with Mitomycin, Cisplatin and Vindesine

作者报告以NIVP（MMC、VDS、DDP）方案治疗非小细胞肺癌（NSCLC）61例的疗效。初治43例，复治18例。本组总有效率为57．37％，既往经合VCR方案治疗失败的病例有效率为38．88％。作者认为MVP方案对NSCLC有较好疗效，且VDS与VCR无完全交叉耐药性。本方案主要毒性为骨髓抑制，值得警惕，其神经毒性轻微，另有一定比例的静脉炎、乏力、脱发、胃肠道反应发生，也应引起注意。

The author reports the therapeutic results Obtained from the treatment of 61 cases of non-small celllung cancer by using WVP(MMC, VDS and DDP) combined program. Forty-three patients received firsttreatment and eighteen, return beatment. For all the patients, the total effective rate was 57. 37 per cent.In those who had failed in NSCLC treatment by use of other therapy including VRC program, the effectiverate was 38. 88 per cent. In author's opinion, MVP program is more effective for NSCLC. Besides, complete cross resistance do not occur when VDS and VCR are used. The main toxic reaction due to thes program is the arrest of bone marrow, which deserves notice, Neurotoxicity of MVP program is slight. Thereoccur certain proportions of phlebitis, lassitude, alopecia and gastrointestinal reactions, which merit our attention.