二硫化碳作业工人临床神经电生理研究

Clinical and Electroneurophysiological Studies in Workers Exposed to Carbon Disulfide

目的探讨慢性二硫化碳中毒的早期诊断方法。方法对二硫化碳作业工人进行神经传导速度和脑干听觉诱发电位检测，运用方差分析方法分析检测结果。结果１７５名二硫化碳作业工人与８０例正常人比较，神经传导速度测定１５个参数中的１３个参数差异有显著意义。对５２名二硫化碳作业工人和２６名正常人的脑干听觉诱发电位的分析表明，接触组和对照组、不同工龄组别与对照组间脑干听觉诱发电位Ⅰ、Ⅲ、Ⅴ各主波潜伏时和峰间潜伏时未见差异。结论低水平二硫化碳长期接触对听觉神经传导通路影响不大，二硫化碳作用主要靶部位是周围神经。

o look for early diagnotic methods of chronic CS2 poisoning,a group of carbon disulfide workers were checked with clinical and electroneurophysiological methods including detection of both nerve conduction velocity(NCVs)and brainstem audiotory evoked potentials(BAEP).The results were analyzed by variance analysisNCV measurement of 175 carbon disulfide workers showed that 13 out of 15 electroneurographic parameters had significant differences compared with the control group(80 healthy people)BAEP detection on 52 carbon disulfide workers and 26 healthy volunteers demonstrated that there were on differences in all the indices of BAEP between these two groups despite of the difference in workingperiodTherefore,the conclusion seems that lowlevel exposure to carbon disulfide only has little effect on the audiotory nerve,but the peripheral nerve may be its target site..