消肿止痛胶囊主要药效学研究

Pharmacodynamics of Xiaozhongzhitong Capsules

目的:研究消肿止痛胶囊的药效作用。方法:以大鼠肠系膜微循环法、小鼠疼痛扭体法、小鼠耳肿胀法观察消肿止痛胶囊的药效作用。结果:消肿止痛胶囊能改善大鼠肠系膜微循环障碍,减少由醋酸引起的小鼠疼痛反应,显著抑制二甲苯所致小鼠耳肿胀。结论:消肿止痛胶囊具有活血化瘀、消肿止痛作用,可为临床应用提供实验依据。

OBJECTIVE： To study the pharmacodynamics of Xiaozhongzhitong capsules. METHODS： The pharmacodynamics of Xiaozhongzhitong capsules was studied through rat mesenteric microcirculation test, mouse pain writhing test and mouse ear swelling test. RESULTS： The Xiaozhongzhitong capsules improved rats＇ mesenteric microcirculation disturbance, attenuated the pain action of mouse induced by acetate acid, and significantly inhabited the ear swelling of mouse caused by dimethylbenzene. CONCLUSION： Xiaozhongzhitong capsules showed proved efficacy in activating blood, dissolving stasis, eliminating swelling and alleviating pain, and the results serve as an experimental basis for the clinical application of Xi-aozhongzhitong capsules.