丝裂原活化蛋白激酶通路与雌激素受体信号调控

Signaling Regulation Between MAPK Pathway and Estrogen Receptors

丝裂原活化蛋白激酶(MAPK)信号转导通路是一组可以被多种细胞外信号激活的丝/苏氨酸激酶,参与细胞的多种生物学行为。雌激素为一种细胞外信号,可以通过雌激素受体(ER)的基因组作用和非基因组作用对细胞功能起调节作用。MAPK信号通路信号转导与ER调控关系密切,其既可以通过ER经典的基因组效应介导多种细胞广泛的生理效应,又可以通过ER非基因组效应实现快速信号通路转导,调控基因转录、细胞的增殖。受体与信号通路之间调控的最终生物学效应可表现在心血管系统、神经系统和恶性肿瘤等诸多方面,就MAPK信号转导通路与ER调控的分子机制及其生物学效应综述。

The mitogen-activated protein kinase （MAPK）intracellular signaling mode is a Ser/Thr-Pro kinase component cassette, enabling the cell to maintain diversity biological behavior while responding to various extracellular stimuli. Estrogen receptors （ERs）mediate the effects of 17b-estradiol under genomic and nongenomic mechanism. The signaling regulation between MAPK pathway and ERs is intimate, ERs trigger classical genomic mechanism of estradiol action in regulation of different physiological functions, while estradiol can also exert through a rapid transduction way to regulate gene transcription and cell proliferation by its nongenomic mechanism. This complex network of intracellular signaling result critical functional processes in cardiovascular system, nervous system and tumor. Here, we summarize the recent findings related to signaling regulation responsible for MAPK pathway and ERs.