口服避孕药物与静脉血栓性疾病

Taking contraceptives orally and venous thrombotic diseases

口服避孕药物可增加静脉血栓性疾病的发病风险,凝血系统遗传异常状态者(如先天性抑凝血物质缺乏、凝血因子VLeiden突变、凝血酶原基因突变者)服用口服避孕药物后其静脉血栓性疾病的发病风险增加。因此,对选择口服避孕药物进行避孕的女性,尤其是有静脉血栓性疾病家族史、既往史以及不良孕产史的女性,在服药前应系统咨询并考虑进行遗传学筛查。

Recent findings show that the use of oral contraceptives increases the risk of venous thromboembolism. The combination of oral contraceptives and the thrombophilia greatly increase the risk of venous thromboembolism, particularly in women with hyperhomocysteinaemia, factor V Leiden and the prothrombin-gene mutation. So prospective users of oral contraceptives are potential candidates for systematical counseling and thrombophilia screening, especially those with the history or family history of venous thromboembolism and those who had adverse pregnancy outcomes.