摘要
目的:研究抑癌基因P16与宫颈癌发生、发展及患者预后的关系。方法:用免疫组化ABC法检测了10份正常宫颈组织、16份慢性宫颈炎及123份宫颈鳞癌组织中P16的表达情况。结果:P16在宫颈癌中检出率为43.90%,明显低于正常宫颈(80.00%)及宫颈炎组织(68.75%),P<0.01。其中伴淋巴结转移的宫颈癌中P16蛋白表达率(22.22%)是显著低于无淋巴结转移者(61.11%),P<0.05。P16蛋白表达阳性者5a存活率为52.63%,而阴性者仅为29.79%,P<0.05。结论:P16蛋白的突变与缺失可能与宫颈癌的发生、发展密切相关。
To research the relationship among tumor suppressor gene p16 expression and cervical carcinoma occurrence, development and patient's prognosis. Methods: ABC immunohistochemistry was employed to detect the expression of p16 protien in tissues of 10 normal uterine cervix, 16 chronic cetvicitis and 123 cervical squamous carcinoma. Results:The positive rate of p16 was significantly lower in carcinoma (43. 90% ) than that in normal uterine cervix (80. 00 % ) , cervicitis(68. 75 % ), P<0. 01, the positive rate in cervical carcinoma with lymph node metastasis(22. 22 % )was markedly lower than that in nonmetastasis(61. 11 % ), P<0. 05. Patients with positive p16 expression had a much high 5 a survival rate (52. 63% ) than that with negative expression (29. 79% ), P < 0. 05.Conclusion: The mutation and deletion of p16 protein may be related to the genesis and development of the uterine cervical carcinoma.
出处
《现代妇产科进展》
CSCD
1998年第1期11-14,共4页
Progress in Obstetrics and Gynecology
关键词
子宫颈肿瘤
P16蛋白
抑癌基因
免疫组织化学
Uterine cervical neoplasms
p16 protein
Tumor suppressor oncogene
Immunohistochemistry.