Biodistribution characteristics of ^(188)Re-TSC after TAE in rabbits bearing VX_2 liver tumor

188Re-tin sulfur colloid(TSC) was prepared to compare its biodistribution characteristics with 188Re-macroaggregates album(MAA) after transhepatic arterial embolization(TAE) in rabbits bearing VX2 liver tumor.Labeling efficiencies of the 188Re-TSC and 188Re-MAA were 99.94%±0.04% and 99.95%±0.03%,respectively,and they were stable for 72 h in human serum.Sintigraphy and biodistribution in 31 rabbits bearing VX2 liver tumor after transcatherter hepatic arterial injection of the radiopharmaceuticals were performed,and relevant activity accumulated mostly in the tumor.The percentage of the injected dose per gram of wet tissue(%ID/g) of 188Re-TSC and 188Re-MAA were calculated.Tumor uptake of 188Re-TSC at 1 h and 24 h were 24.32%±11.93% and 21.88%±18.29%,and the radioactive ratios of tumor/liver were 70.89±19.58 and 17.42±13.96,respectively.Tumor uptake of 188Re-MAA at 1 h and 24 h were 38.78%±30.23% and 15.98%±26.64%,and the radioactive ratio of tumor/liver of 188Re-MAA were 39.71±25.06 and 8.13±4.61,respectively.188Re-TSC is a potential radiopharmaceutical for the therapy of tumors.

^188Re-tin sulfur colloid （TSC） was prepared to compare its biodistribution characteristics with ^188Re-macroaggregates album （MAA） after transhepatic arterial embolizafion （TAE） in rabbits hearing VX2 liver tumor. Labeling efficiencies of the ^188Re-TSC and ^188Re-MAA were 99.94%±0.04% and 99.95%±0.03%, respectively, and they were stable for 72h in human serum. Sintigraphy and biodistribution in 31 rabbits bearing VX2 liver tumor after transcatherter hepatic arterial injection of the radiopharmaceuticals were performed, and relevant activity accumulated mostly in the tumor. The percentage of the injected dose per gram of wet tissue （%ID/g） of ^188Re-TSC and ^188Re-MAA were calculated. Tumor uptake of ^188Re-TSC at 1h and 24h were 24.32%±11.93% and 21.88%±18.29%, and the radioactive ratios of tumor/liver were 70.89±19.58 and 17.42±13.96, respectively. Tumor uptake of ^188Re-MAA at 1h and 24h were 38.78%±30.23% and 15.98%±26.64%, and the radioactive ratio of tumor/liver of ^188Re-MAA were 39.71±95.06 and 8.13±4.61, respectively. ^188Re-TSC is a potential radiopharmaceutical for the therapy of tumors.