超顺磁性氧化铁粒子(SPIO)的弛豫率及磁化率研究

EXPERIMENTAL STUDY ON THE RELATLIVITY AND MAGNETIC SUSCEPTIBILITY OF SUPERPARAMAGNETIC IRON OXIDE(SPIO) CONTRAST AGENT

本文采用Ｃａｒｒ－Ｐｕｒｅｌ－Ｍｅｉｂｏｏｍ－Ｇｉｌ序列及古埃氏法分别测定了超磁显注射液与Ｅｎｄｏｒｅｍ的弛豫率和磁化率，结果表明：超磁显注射液的Ｔ２弛豫率与磁化率分别为０．１３８２９×１０６ｍｏｌ－１．ｓｅｃ－１和３０３４６×１０－６ｃｇｓ／ｇＦｅ，与进口Ｅｎｄｏｒｅｍ的Ｔ２弛豫率（０．１６５７１×１０６ｍｏｌ－１·ｓｅｃ－１）及磁化率（３４６５８×１０－６ｃｇｓ／ｇＦｅ）十分相近。我们制备的超磁显注射液与进口同类产品Ｅｎｄｏｒｅｍ具有相似的磁学特性及相似的造影效果。

the magnetic properties including relaxivity and magnetic susceptibility of Chao Ci Xian injection synthesized by authors were investigated.The Properties were compared with that of commercial preparationEndorem (Guerbet,Paris,France).Material and Methods:MR transvsere relaxivity was determined with a CarrPurcellMeiboomGill Sequence in 1.5Tesla MR System.The magnetic susceptibility was measured by traditional Gouy method.Results:The T2 relaxivities for both Chao Ci Xian injection and Endorem were 0.13829×106mol1.sec1 and 0.16571×106mol1.sec1 respectively. Moreover,magnetic susceptibilities of Chao Ci Xian injection and Endorem were 30346×106c.g.s/gFe and 34658×106c.g.s/gFe respectively.Conclusion:The effects of T2 relaxivity and magnetic susceptibility presented by both SPIO contraotagents were similar.therefore Chao Ci Xian injection is a potential effective MR contrast agent