摘要
Objective： To observe the effects of herbal cake-partitioned moxibustion and bran-partition moxibustion in improving symptoms of ulcerative colitis （UC） and the TNF-α and its receptor of colon mucosa. Method： 67 UC cases were randomly allocated into herbal cake-partition moxibustion group of 35 cases and bran-partitioned moxibustion group of 32 cases, to compare the improvement and detect the TNF-α and its receptor with immunohistochemical method in both groups. Result： Herbal cake-partitioned moxibustion is prior to bran-partitioned moxibustion in improving of diarrhea, flatus, lassitude, tenesmus and lumbar soreness; The expression of TNF-α,TNF-αR1, and TNF-αR2 are significantly decreased after treatment in herbal cake-partitioned moxibustion group, while in bran-partitioned moxibustion group only TNF-αR1 expression is significant decreased after treatment. Conclusion： Moxibustion can well improve the syndromes of UC, Herbal cake-partitioned Moxibustion is prior to bran-partitioned moxibustion in the improvement of diarrhea and flatus; Herbal cake-partitioned moxibustion could down-regnlate the expression of TNF-α,TNF-αR1, and TNF-αR2, while bran-partitioned moxibustion could only down-regulate the expression of TNF-αR1.
目的:观察隔药灸、隔麸灸对溃疡性结肠炎(UC)患者症状的改善作用和对结肠黏膜TNF-α及其受体的影响。方法:将67例UC患者随机分为隔药灸组(35例)和隔麸灸组(32例),对比观察两组患者症状的改善情况,并采用免疫组织化学法观察两组结肠黏膜TNF-α及其受体的变化。结果:隔药灸组在腹泻、矢气、神疲乏力、里急后重、腰酸症状的改善方面优于隔麸灸组;隔药灸组结肠黏膜TNF-α、TNF-αR1、TNF-αR2的表达均较治疗前显著下降,隔麸灸组仅见TNF-αR1较治疗前显著下降。结论:艾灸对UC患者各项症状均有较好的改善作用,在腹泻、矢气等部分症状的改善方面,隔药灸优于隔麸灸;隔药灸能够下调结肠黏膜TNF-α、TNF-αR1、TNF-αR2的表达,隔麸灸仅能下调TNF-αR1的表达。
