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胃液颈细胞分化增殖的调控

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摘要 黏液颈细胞(MNC)被认为是胃黏膜中具有分化和增殖能力的细胞,研究显示再生基因RegI可促进MNC向壁细胞和主细胞分化,在胃黏膜细胞增生、移行、分化以及维持胃黏膜完整性中发挥重要作用。研究发现表皮生长因子(EGF)、胃泌素和促炎性因子CINC-2β可能都通过刺激RegI来调节MNC的细胞分化和胃腺体增殖。胃泌素促进ECL细胞中RegI的表达,胃黏膜MNC抗EGF抗体强染色,而其他胃黏膜细胞(主细胞、壁细胞等)均无阳性表达。在转基因大鼠实验中,转化生长因子表达后,MNC细胞和腺体黏液细胞数量明显增加。此文综述并提出了MNC分化和增殖对胃黏膜良恶性病变影响的机制。
出处 《国际消化病杂志》 CAS 2009年第2期116-118,共3页 International Journal of Digestive Diseases
基金 浙江省自然科学基金(Y206280) 浙江省教育厅科研项目(Y200702882)
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参考文献22

  • 1Hanby AM, Poulsom R. Playford RJ, et al. The mucous neck cell in the human gastric corpus: a distinctive, functional cell lineage. J Pathol, 1999, 187:331-337.
  • 2Karam SM, Leblond CP. Dynamics of epithelial cells in the corpus of the mouse stomach. Ⅲ. Inward migration of neck cells followed by progressive transformation into zymogenic cells. Anat Rec, 1993, 236:2c)7-313.
  • 3Karam SM. Dynamics of epithelial cells in the corpus of the mouse stomach. IV. Bidirectional migration of parietal cells ending in their gradual degeneration and loss. Anat Rec, 1993, 236:314-332.
  • 4Dixon MF. Prospects for intervention in gastric carcinogenesis:reversibility of gastric atrophy and intestinal metaplasia. Gut, 2001,49:2-4.
  • 5Brembeck FH,Sehreiber FS, Deramaudt TB, et al. The mutant K-ras oncogene causes pancreatic periduetal lymphocytic infiltration and gastric mucous neck eell hyperplasia in transgenie mice. Cancer Res,2003,63:2005- 2009.
  • 6Yoshikazu K, Shunji I. Mechanism of gastric mucosal proliferation induced by gastrin. J Gastroenterol Hepatol,2000,15(Suppl): 7-11.
  • 7Yonemura Y, Takashima T, Miwa K, et al. Amelioration of diabetes mellitus in partially depancreatised rats by poly(ADP- ribose) synthetase inhibitors. Diabetes, 1984, 263:2111- 2114.
  • 8Hartupee JC. Zhang H, Bonaldo MF, et al. Isolation andeharacterization of a cDNA encoding a novel member of the human regenerating protein family: RegIV. Biochim Biophys Acta, 2001, 1518:287-293.
  • 9Watanabe T, Yonekura H, Terazono K, et al. Complete nucle otide sequence of human reg gene and its expression in normal and tumoral tissues. J Biol Chem, 1990, 265:7432-7439.
  • 10Miyaoka Y, Kadowaki Y, Ishihara S, et al. Transgenie overex pression of Reg protein caused gastric cell proliferation and dif ferentiation along parietal cell and chief cell lineages. Oncogene 2004, 23 :3572.

二级参考文献8

  • 1姒健敏,王良静,陈淑洁,朱方石,钱云,徐妙.鼠慢性萎缩性胃炎胃黏膜形态特征和细胞增殖调控因子变化研究[J].中华消化杂志,2004,24(8):476-479. 被引量:13
  • 2Celebi N,Turkyilmaz A,Gonul B,et al.Effects of epidermal growth factor microemulsion formulation on the healing of stress-induced gastric ulcers in rats.J Control Release,2002,83:197-210.
  • 3Sinha A,Nightingale J,West KP,et al.Epidermal growth factor enemas with oral mesalamine for mild-to-moderate left-sided ulcerative colitis or proctitis.N Engl J Med,2003,349:350-357.
  • 4Tran CD,Howarth GS,Coyle P,et al.Dietary supplementation with zinc and a growth factor extract derived from bovine cheese whey improves methotrexate-damaged rat intestine.Am J Clin Nutr,2003,77:1296-1303.
  • 5Shimamoto C,Hirata I,Umegaki E,et al.Gastric mucosal cell protection by epidermal growth factor in primary monolayer culture of guinea pig gastric mucous cells.J Gastroenterol,2003,38:727-733.
  • 6Jansen C,Ihse I,Axelson Epidermal growth factor induces increased mucosal thickness of the small intestine in mouse.Eur Surg Res,1997,29:447-454.
  • 7姒健敏,吴加国,曹倩,项尊,姜玲玲,吕文,黄怀德.鼠慢性萎缩性胃炎模型的建立及致萎缩因素探讨[J].中华消化杂志,2001,21(2):75-78. 被引量:82
  • 8李红涛,吴开春,李彩宁,乔泰东,郭学刚,王新,郝志明,宋瑛,丁杰,樊代明.血清胃泌素对老年人慢性萎缩性胃炎的诊断[J].中华老年医学杂志,2004,23(4):238-240. 被引量:29

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