结直肠癌与糖尿病的关系及螺旋CT分析

Role of colorectal cancer in type 2 diabetes mellitus and helical CT analyzing

目的探讨结直肠癌(CRC)合并糖尿病的发病率、年龄分布、肿瘤解剖部位以及转移发生情况等方面的关系。方法回顾性分析156例经手术或肠镜活检经病理证实的CRC患者的临床及CT资料,其中36例伴发2型糖尿病,将其定为CRC伴糖尿病组,剩余120例为CRC非糖尿病组,此文结合CT重点分析CRC伴发糖尿病的发病率、年龄分布、肿瘤解剖部位及转移等方面的情况。结果CRC与糖尿病共病的粗略发病率占23.08%,经年龄构成结构进行调整后,得出2型糖尿病的标准患病率为5.76%,明显高于1995至1997年全国糖尿病标准化患病率3.21%,经统计学处理两者有统计学差异(P<0.01)。伴发糖尿病组CRC淋巴结及远处转移率占43.5%,较非糖尿病组23.33%转移率高,比较两者差异有统计学意义(P<0.01)。结论CRC患者中2型糖尿病发病率较普通人群高,70～80岁为多发年龄段,远端结肠癌伴发糖尿病概率高,CRC合并糖尿病时更容易发生淋巴结及远处转移。

Objective To figure out the proportion of type 2 diabetes mellitus among colorectal cancer（CRC） patients adjusting anatomic site distribution and the rate of metastasis in CRC complicated with type 2 diabetes mellitus. Methods The clinical data of 156 CRC patients were reviewing analyzing divided into two groups according to whether or not they got type 2 diabetes mellitus. Their clinical data were reviewed and analyzed to adjusting anatomic site distribution and the rate of metastasis of type 2 diabetes mellitus. Results The standardized prevalence of type 2 diabetes mellitus among CRC patients was 5.76%, significantly greater than that of national diabetes 3.21% screening between 1995 and 1997 （P〈0. 01）. The rate of metastasis of lymph node of other organs increased in type 2 diabetes mellitus complicated with CRC than that in without type 2 diabetes mellitus （43.5% vs 23.33%） （P〈0.01）. Conclusion The type 2 diabetes mellitus among CRC patients was significantly greater than that of national diabetes. 70-80 years is frequently. The type 2 diabetes mellitus among CRC patients in distal colon the incidence of a disease is higher than that in proximal colon and rectal colon. The rate of metastasis of lymph node of oth er organs increased in CRC complicated with type 2 diabetes than that in CRC patients without type 2 diabetes mellitus.