清热养阴除湿丸对活动期强直性脊柱炎患者血清IL-1β IL-10的影响

The effect of Qingre Yangyin Chushi Pill on serum IL-1β and IL-10 levels in active stage of ankylosing spondylitis patients

目的:探讨清热养阴除湿丸对活动期强直性脊柱炎(AS)患者血清白细胞介素(IL-1β、IL-10)水平的影响,以评价本药的临床疗效的药理机制。方法:随机选取57例活动期强直性脊柱炎患者为治疗组,并设正常对照组,观察治疗组治疗前后临床症状及血中IL-1β、IL-10水平的变化。结果:活动期强直性脊柱炎患者经清热养阴除湿丸治疗后,患者血清IL-1β水平降低,而IL-10含量升高(P≤0.05)。结论:清热养阴除湿丸通过祛湿除寒,清热化湿,活血化瘀等药理作用,降低IL-1β含量,同时上调IL-10水平,使患者体内免疫调节趋向正常。

Objective：To assess drug＇s pharmacological mechanisms,the effects ofQingre Yangyin Chushi pill（QRYYCSP） on serum interleukin（IL-1β and IL-10） levels in patients in active stage of ankylosing spondylitis were investigated.Methods：Randomly selected 57 patients with active ankylosing spondylitis were treated with QRYYCSP for two months in treating group,and 31 healthy cases were as a normal control group,and serum IL-1β and IL-10 level changes were observed before and after treatment.Results：The serum reducing IL-1β content and raising IL-10 levels were observed in treated by QRYYCSP patients in active stage of ankylosing spondylitis（P≤0.05）.Conclusion： The study suggested that QRYYCSP exhibited promoting blood circulation pharmacological effect,reducing serum IL-1β content,while raising the level of IL-10 in patients with normal immune regulation trends.