加味苇茎汤治疗慢性阻塞性肺疾病急性发作期临床研究

Clinical Research on Efficacy of Acutely Exacerbated Chronic Obstructive Pulmonary Disease(AECOPD) with Modified Weijing Decoction

目的:观察加味苇茎汤对COPD急性加重期患者的临床症状及体征、血气分析、外周血TNF-α、IL-8水平的影响。方法:将60例COPD急性加重期(分级为I^III级)证属痰热阻肺型患者随机分为治疗组和对照组。对照组采用西医常规治疗(控制性氧疗、支气管舒张剂、抗生素、祛痰药),治疗组在对照组治疗的基础上,加用加味苇茎汤,疗程为10天。比较两组治疗前后的临床症状及体征、血气分析、外周血TNF-α、IL-8水平的变化。结果:加味苇茎汤可以缓解患者临床症状,改善缺氧及二氧化碳潴留,降低外周血IL-8、TNF-α水平。结论:加味苇茎汤具有较好的缓解临床症状和体征,改善缺氧及二氧化碳潴留情况,同时抑制肺部炎症反应的综合作用。

Objective： The aim of the study was to assess the clinical effect and the influence and meanings to the level of TNF-α and IL-8 in the peripheral blood with the Modified Weijing Decoction.Methods：Sixty hospitalized AECOPD patients（stage phlegm and heat syndrome in the lung in TCM are I^III） with retention of randomly divided into two groups,the trial group and the control group.The patients of trial group take the Modified Weijing Decoction which has the efficacy of clearing away heat-evil and resolving phlegm.The period of treatment is 10 days.To compare the result of two groups by analyzing clinical symptom and sign,blood gas analysis,the level of TNF-α and IL-8.Results： Clinical symptom and sign： After the treatment,melioration of clinical symptom and sign in both groups have significant difference.The Modified Weijing Decoction can help to improve the indexes of blood gas analysis,and the trial group is superior to the control group.TNF-α and IL-8 in the peripheral blood of both groups reduce,showing significant difference.we can see that the effect of the trial group on reducing TNF-α,IL-8 in the peripheral blood is more significant than the one of the control group.Conclusion： The management of clear away heat and disperse phlegm combination with routine western medicine reduced syndrome,improved anoxia and carbon dioxide retention and debased the level of IL-8,TNF-α relative to group by routine western medicinein clinical trials on patients with AECOPD by Phlegm and heat syndrome in TCM.