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细胞因子FAM3家族研究进展

Progresses in research of FAM3 family
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摘要 FAM3家族是2002年新发现的一个细胞因子样基因家族,由FAM3A、FAM3B、FAM3C和FAM3D 4个成员组成,分别编码含有224-235个氨基酸残基的多肽,它们在二级结构上都具有4个α螺旋。这种二级结构特征与一些细胞因子相似。本文综述了FAM3家族成员的基因定位及结构、基因表达和分泌的调控,以及生理功能和病理意义的研究进展。 FAM3 family is a novel cytokine-like gene family identified in 2002. There are four members in this family （FAM3A, FAM3B, FAM3C and FAM3D）, which encode proteins consist of 224-235 amino acids. All members contain a predicted secondary structure of four-helix bundle which exist in many other cytokines. In this review, we describe the current understanding of molecular structure, regulation of expression, biological functions and pathophysiological significance of the members of FAM3 family.
作者 王欧美 乐颖影
机构地区 中国科学院上海生命科学研究院营养科学研究所
出处 《生命科学》 CSCD 北大核心 2009年第2期280-285,共6页 Chinese Bulletin of Life Sciences
基金 国家自然科学基金(30870931) 中国科学院上海生命科学研究院首席科学家项目(SIBS2008006)
关键词 FAM3家族 表达调控 细胞凋亡 FAM3 family gene expression apoptosis
分类号 Q516 [生物学—生物化学] Q255 [生物学—细胞生物学]
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二级参考文献34

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生命科学
2009年 第2期

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