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线粒体DNA与DNA甲基化的关系 被引量：1

The relationship between mitochondrial DNA and DNA methylation
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摘要 线粒体DNA(mitochondrial DNA,mtDNA)遗传信息量虽小,却控制着线粒体一些最基本的性质,对细胞及其功能有着重要影响。mtDNA的损伤与衰老、肿瘤等疾病的发生有关。DNA甲基化是调节基因表达的重要方式之一。mtDNA基因的表达受核DNA(nuclear DNA,nDNA)的调控,mtDNA和nDNA协同作用参与机体代谢调节和发病。本文就近年来mtDNA与DNA甲基化的关系作一综述。 Mitochondrial DNA（mtDNA） determines the primary nature of mitochondrial and plays an important role in cell function.The damage of mtDNA is associated with aging, tumor and other diseases. DNA methylation is a major way to regulate gene expression, mtDNA expression is regulated by nuclear DNA. mtDNA and nDNA participating in metabolic regulation and pathogenesy synergisticly. The relationship between mitochondrial DNA and DNA methylation were reviewed here.
作者 王萍 房静远
机构地区 上海交通大学医学院附属仁济医院
出处 《生命科学》 CSCD 北大核心 2009年第2期291-294,共4页 Chinese Bulletin of Life Sciences
关键词 线粒体DNA DNA甲基化 基因表达 疾病 mitochondrial DNA DNA methylation gene expression disease
分类号 Q523 [生物学—生物化学] Q244 [生物学—细胞生物学]
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参考文献19

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同被引文献29

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生命科学
2009年 第2期

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