摘要
目的在建立慢性病贫血（ACD）大鼠动物模型的基础上，通过检测大鼠肝脏转铁蛋白受体-2（TfR2）在促红细胞生成素（EPO）干预前后的表达情况，探讨其在ACD中的作用。方法在传统佐剂性关节炎大鼠模型基础上，通过追加注射弗氏完全佐剂三次，增强其免疫反应，从而诱发建立贫血模型。对不同处理组大鼠肝脏TfR2mRNA表达水平进行检测。结果ACD模型组大鼠肝脏TfR2 mRNA表达比正常对照组升高（P=0．001），贫血明显；EPO治疗组肝脏TfR2 mRNA表达比ACD模型组大鼠降低（P=0．001），贫血改善。结论TfR2可能与ACD有关。
Objective Based on establishing a rat model of anemia of chronic disease （ACD）, expression of transferrin receptor 2（TfR2） in the liver cultured with erthropoietin（EPO） and cultured without EPO to the action of TfR2 in the ACD were detected. Methods Anemia was induced by injecting freund adjuvant for third times to the traditional model rats of adjuvant arthritis to enhance their immune responses the levels of the expression level of TfR2 mRNA in the livers of rats among different treated groups were compared. Results In the ACD group the expression of TfR2 mRNA in the livers of rats was higher than in the normal control goup（P =0.001）, is significant in anemia; while in the EPO therapy group the expression of TfR2 mRNA was less than in the ACD goup （P =0.001）, is improved in anemia. Conclusion TfR2 may be revalant to ACD.
出处
《白血病．淋巴瘤》
CAS
2009年第4期206-209,共4页
Journal of Leukemia & Lymphoma
关键词
受体
转铁蛋白
慢性病
贫血
红细胞生成素
Receptors, transferrin
Chronic disease
Anemia
Erythropoietin
