CRP、Ps、IL-6与急性冠脉综合征病变及预后相关性研究

Study of the relativity between CRP,Ps,IL-6 and acute coronary syndromes

目的探讨C-反应蛋白(C-reactive protein,CRP)、P-选择素(P-selectin,Ps)、白细胞介素-6(interleukin-6,IL-6)等炎症标志物与急性冠脉综合征(acute coronary syndrome,ACS)的关系。方法测定126名冠心病患者入院及出院时血中CRP、Ps、IL-6浓度,分析它们与ACS患者病情、冠脉病变程度的关系并观察心脏事件的发生率。结果ACS患者CRP、Ps、IL-6浓度较对照组明显增高(P<0.01),并随病情严重程度增加而增高(急性心肌梗死>不稳定性心绞痛>稳定性心绞痛,P<0.05),也随病变冠脉数量的增加而增高(三支病变组>二支病变组>单支病变组,P<0.05);住院及随访期间发生心脏事件与未发生患者组之间CRP、Ps、IL-6浓度比较,差异均有统计学意义(P<0.01)。结论炎症反应与ACS的发生、发展有关,监测血中CRP、Ps、IL-6等炎症标志物的水平对判断ACS诊断、临床预后评估及中、近期心脏事件发生有较高的预测价值。

[Objective] To study of the relativity between C-reactive protein （CRP）, P-selectin （Ps）, interleukin- 6 （IL-6） and acute coronary syndrome （ACS）. [Methods] The serum CRP, Ps, IL-6 and progression of coronary artery in 126 patients with ACS at hospitalization and discharging were measured, their rate of major adverse cardiac events （MACE） were observed. [Result] The levels of serum CRP, Ps, IL-6 in patients with ACS were significantly higher than normal controls （P 〈0.01）, the severer the disease, the higher the levels （stable angina peetoris 〈 unstable angina pectoris 〈 acute myocardial infarction）. They also increased with the increasing extent of the numbers of diseased coronary vessels （the 3-vessel-disease group 〉 the 2-vessel-disease group 〉 the 1-vessel- disease group, P 〈0.05）, Among them, the levels of serum CRP, Ps and IL-6 in patients with cardiac events were significantly higher than others were in hospital and in following 12 months （P 〈0.01）. [Conclusion] Inflammatory reaction was closely associated with ACS, monitoring the levels of CRP, Ps and IL-6 are impoi＇tant to diagnosis, treatment, prognosis and anticipant value for shot and long -term cardiac events.