中国南海总合草苔虫中新的抗癌活性成分Bryostatinl9

BRYOSTATIN19: A NEW ANTINEOPLASTIC COMPONENT FROM BUGULA NERITINA IN THE SOUTH CHINA SEA

自我国南海采集的总合草苔虫中,经多种层析方法分离到一种新的大环内酯化合物,应用化学方法和现代光谱技术(UV,IR,ESI-MS,~1HNMR,^(13)CNMR,2DNMR)确定了它的化学结构,并命名为bryo-statin19。体外抗癌活性试验表明,该化合物对U937单核细胞白血病细胞株有极强的杀灭作用,(ED_(50)=2.8×10^(-3)μg/ml),同时对HI-60早幼粒白血病和K562红白细胞白血病等细胞株均有显著的抑制作用。

A now bryostatin was isolated from Bugula neritina growing in the south China sea by various chromatography. Its structure was elucidated by chemical evidence and spectroscopic data (UV, IR, ESI-MS, 1HNMR, 13CNMR, 2DNMR) and named as bryostatin 19- The new compound showed a significant antineoplastic acitivity against U937 (ED50 = 2. 8 X10-3ug/ml),HL-60 and K562 leukemia cells in vitro.