天津市肺肿瘤3177例临床病理资料分析

Clinicopathologic Analysis of Patients with Lung Tumors of 3177 cases in Tianjin

目的探讨1980～2007年28年天津市肺肿瘤尤其是肺癌的发病趋势及特点,为临床和病理医师提供诊断参考。方法选自天津医科大学总医院和第二附属医院病理科1980～2007年外科手术和活检病理档案中的肺原发肿瘤3177例,应用SPSS11.5统计软件包对该资料进行统计分析。结果近28年来,肺癌占外检总数和恶性肿瘤数的百分比均呈上升趋势(P<0.05)。肺癌中女性占29.5%,与男性相比检出绝对量增长较快且构成比逐渐增加(P=0.040)。在增加的可手术切除的病例中,腺癌和大细胞癌构成比有所上升,鳞癌和小细胞癌有所下降。青年组、中年组、老年组组织学类型有显著性差异(P=0.000),青年组以腺癌为主,而中、老年组均以鳞癌为主。结论肺癌尤其是女性肺癌检出率增加,肺癌的组织学类型也有所改变,应引起临床和病理医师的注意。

Objective To study clinicopathological characteristics and tendency of incidence of lung tumors from 1980 to 2007 in Tianjin and to provide information for pathologists and clinicians. Methods The data of lung tumors are collected from General Hospital and the Second Hospital of Tianjin Medical University. The data are analyzed by SPSS11.5. Results Both of the ratios （the ratios of lung cancer to the total and lung cancer to the malignant tumors） have been increasing druing 28 years（P〈0. 05）. Among 3 075 cases females are accounting for 29. 5 %, and the cases of females have been increasing further than males. The ratio to the total among the corresponding time period has the same trend （P = 0. 040）. The ratio of adencarcinoma and large cell carcinoma is increasing while the ratio of squmous cell carcinoma and small cell carcinoma is decreasing. The cases of youngers have been also increasing and its proportions of histological types of lung cancers has a significant different compared with the middle-aged and olders（P = 0. 000）. Adencarcinoma is the main type of youngers while squamous cell carcinoma is the main type in both the middle-aged and olderly group. Conclusion The detection rate of lung carcinoma especilly carcinoma in females is increasing, and the subtypes of lung carcinoma also changed.