老年急性髓细胞白血病患者FLT3表达的意义

Expression of FLT3 in elderly patient’s acute myeloid leukemia

目的研究老年急性髓细胞白血病(AML)患者Fms样的酪氨酸激酶3(FLT3)的表达水平,探讨其在老年AML中的作用机制及临床意义。方法采用半定量RT-PCR方法检测36例老年AML和11例良性血液病为对照组FLT3表达水平。结果36例老年AML组表达水平明显高于对照组,差异有统计学意义(P<0.001);复发难治组最高,初治组居中,完全缓解组最低,三者表达水平具有显著性差异(P<0.05)。结论FLT3在老年AML中存在过度表达,提示FLT3在老年AML的发病机制中有一定作用。FLT3表达水平与疾病进展及预后相关。在检测微小残留病,估计残留白血病细胞负荷量,也可能有一定价值。

Objective To investigate expression level of FLT3 in elderly patients with acute myeloid leukemia （AML）, and evaluate the role of FLT3 in elderly AML patients and its clinical significance.Methods The semi-quantitative RT-PCR method was performed to detect the expression levels of FLT3 in the bone marrow samples of 36 elderly patients with AML, and 11 samples of benign hemopoietic patients. Results The expression level of FLT3 was significantly higher in elderly AML patients than the control group （P 〈 0.001 ）. The expression level of the refractory or relapse AML was the highest, de novo AML was in the middle and the complete remission AML was the lowest. The differences of FLT3 expression level in three groups were statistic significant（P 〈 0.05 ）.Conclusion The over expression of FLT3 may play an important role in leukemogenesis. The expression level of FLT3 is correlated with progression and prognosis of elderly patients with AML. It has the potential to use as a mark to monitor the minimal residual disease.