实时心肌超声造影评价X综合征患者心肌冠状动脉血流储备

Detection of myocardial coronary flow reserve of syndrome X by real-time myocardial contrast echocardiography

目的应用实时心肌超声造影评价X综合征患者心肌冠脉血流储备。方法选择X综合征患者10例，对照组7例，应用超声造影剂SonoVue进行实时心肌超声造影检查，分别测定静息状态和腺苷负荷后造影剂微泡达到峰值的最大声强度（A），再充盈平均速度（β）及AXB，并测定冠脉血流储备（负荷前后AXB的比值）。结果X综合征患者静息时A与对照组相比差异无统计学意义（P〉0．05），β值和AXD值低于对照组（P〈0．01），X综合征患者冠状动脉血流储备值明显低于对照组，差异有统计学意义（P〈0．01）。结论X综合征患者心肌微血管功能受损，实时心肌超声造影可评价X综合征患者心肌冠脉血流储备。

Objective To evaluate myocardial coronary flow reserve of syndrom X by real-time myocardial contrast echocardiography（MCE）. Methods Ten patients with syndrome X and seven normal subjects were involved in the study. Real time MCE was performed with acoustic contrast SonoVue,and the peak video density （A）, and re-turgor velocity of microvessel （β）, and the product of A × β of quiescent condition and after adenosin loading were detected,and also the coronary flow reserve （CFR, the ratio of A ×β circa-adenosin loading）. Results There was no significant difference of A between syndrom X and contrast group in quiescent condition, the β and product of A × β of patients with syndrome X were lower than those of contrast group, the CFR of syndrome X was obviously less than that of contrast group. Conclusions Myocardial microvessel function is abnormal in syndrome X, real-time MCE is useful for evaluate myocardial coronary flow reserve.