未服药与短期服药治疗的精神分裂症患者执行功能的对照研究

Comparison of Wisconsin Card Sorting Test Between Neuroleptic-naive and Short-term Medicated Onset Schizophrenic Patients

目的:探讨未服药与短期服药治疗的发作期精神分裂症患者执行功能的特点。方法:采用威斯康星分类卡片测验(WCST)分别对50名未服抗精神病药物、47名服药治疗不足1月的处于发作期、现病期在2年以内的分裂症患者和60名健康对照者的执行功能进行评估。结果:①在WCST中,未服药和服药的分裂症患者的总反应数、持续错误数、随机错误数、错误应答百分率和随机错误应答率均高于正常对照组(均P<0.05);两患者组正确反应数、完成分类数和正确应答百分率均低于对照组(均P<0.05)。②WCST中持续错误数与患者的性别、年龄、教育年限的相关关系无显著性(均P>0.05)。结论:未经治疗和短期治疗的急性发作期分裂症患者均存在执行功能缺陷。

Objective： To explore the executive function of neuroleptic-naive and short-term medicated onset schizophrenic patients. Methods： 55 drug naive patients and 49 patients with schizophrenia medicated for one month and 60 normal controls were administered the Wisconsin Card Sorting Test （WCST） to study the executive function. Results： Compared with the controls, neuroleptic-naive patients and medicated patients showed higher level in the number of total trials, perseverant errors, random errors, the rate of error responses and the rate of random errors, while they showed lower level in the number of categories, correct trials and the rate of correct responses. There was no significant difference in WCST between the neuroleptic-naive patients and medicated patients. Conclusion： Neuroleptic-naive and short-term medicat,.d onset patients with schizophrenia may have executive dysfunction.