妊娠肝内胆汁淤积症妇女血清一氧化氮水平的研究

The Changes of Serum Nitric Oxide Level in Patients with Intrahepatic Cholestasis of Pregnancy

目的探讨一氧化氮（ＮＯ）与妊娠肝内胆汁淤积症（ＩＣＰ）病理生理变化之间的关系。方法采用Ｇｒｅｉｓｓ法测定４９例ＩＣＰ妊娠妇女（ＩＣＰ组）外周血中ＮＯ的含量，同期住院的正常晚期妊娠妇女２６例（正常妊娠组）作为对照。结果ＩＣＰ组妊娠妇女血清ＮＯ含量较正常晚期妊娠组明显降低（Ｐ＜０．０１）；ＩＣＰ组妊娠妇女血清ＮＯ水平与瘙痒症状持续时间、血清胆红素和转氨酶值的高低有关，而与血清甘胆酸（ＣＧ）无相关性。ＩＣＰ组平均孕龄较正常妊娠组缩短，平均新生儿体重显著低于正常妊娠组。结论ＮＯ参与了ＩＣＰ的病理生理变化过程，与ＩＣＰ妊娠妇女并发的胎儿宫内发育迟缓（ＩＵ－ＧＲ）、早产。

Objective To study the relationship of serum nitric oxide (NO) level with pathophysiological changes in intrahepatic cholestasis of pregnancy (ICP). Methods 49 patients with ICP and 26 healthy women in their late pregnancy were studied. The serum NO levels were determined with Greiss reaction by measuring oxidation products of NO. Results The serum NO concentration in patients with ICP decreased significantly when compared with that of healthy pregnant women. The serum NO level in patients with ICP was related to the time of persistent pruritis, the serum concentration of bilirubin and glutamic pyruvic transaminase (GPR). There is no correlation between serum NO and cholylglycine. In the ICP group the average gestational age was shorter than that of normal pregnancy and the weight of newborn was also lower. Conclusions The decline of serum NO may play an important role in the pathophysiological changes in ICP and may cause the intrauterine growth retardation, premature delivery and fetal hypoxia.