葡萄胎的分子遗传学分类与大体病理类型的关系

The Relationship between the Pathological Classifications and Molecular Genetics of Hydatidiform Moles

目的探讨葡萄胎的遗传学类型与病理形态学的关系。方法采用ＤＮＡ限制性片段长度多态性分析的方法研究３２例葡萄胎标本。结果ＤＮＡ完全来自父源性的葡萄胎有２１例，其中大体病理形态呈完全性葡萄胎者１６例，占７６％（１６／２１），部分性葡萄胎者５例，占２４％（５／２１）；ＤＮＡ来自双亲的葡萄胎１１例，其中大体病理形态呈完全性葡萄胎者５例，占４５％（５／１１），部分性葡萄胎者６例，占５５％（６／１１）；χ２检验结果表明葡萄胎的病理学类型与遗传学类型无明显的平行关系（Ｐ＞０．１０）。

Objective To study the relationship between the pathological classification and molecular genetics of hydatidiform mole. [WT5”HZ〗Method 32 cases of hydatidiform mole were analyzed by DNA restriction fragment length polymorphism (RFLP, hybridized with the probe 33.15). Results DNA from only paternal origin was found in 21, and from both parents in 11. In the formeron the basis of pathological characteristics, the complete hydatidiform mole (CHM) and the partial hydatidiform mole (PHM) were 16 (76%, 16/21) and 5 (24%, 5/21) respectively, and in the later CHM and PHM were 5 (45%, 5/11) and 6 (55%, 6/11), respectively. Conclusion There is not much correlation between pathological classification and molecular genetics of hydatidiform mole.