2型糖尿病患者血栓调节蛋白水平与冠心病的关系

The relathinship of conronary arterial lesion and the plasma thrombomodulin in type 2 diabetes mellitus

目的探讨2型糖尿病患者血栓调节蛋白(thrombomodulin,TM)水平与合并冠心病的关系。方法选择2007年1月至2008年3月在本院住院的97例糖尿病患者,把合并冠心病患者分为稳定性心绞痛组、不稳定性心绞痛组和心肌梗死组。应用酶联免疫吸附测定(ELISA)检测其血浆TM水平,并对血浆TM与冠状动脉病变作相关分析。结果不稳定性心绞痛组血浆TM水平高于稳定性心绞痛组;心肌梗死组明显高于不稳定性心绞痛组。结论2型糖尿病合并冠心病患者,随着冠状动脉粥样硬化病变程度加重,血浆TM水平可能相应升高。监测2型糖尿病患者血浆TM水平,对预测其冠状动脉粥样硬化病的严重程度可能有一定意义。

Objective To evaluate the relationship between the plasma thrombomodulin level and severity of coronary arterial lesion in patients with type 2 diabetes mellitus （T2DM） complicated with conronary heart disease. Methods The venous blood samples were obtained from 97 patients with type 2 diabetes mellitus （T2DM） after they were in hosptial. Patients with type 2 diabetes mellitus （T2DM）complicated with coronary heart disease were divided into stable angina pectoris grops, instable angina pectoris grops and myocardial infarction group. The the plasma thrombomodulin levels were determined by enzyme-linked immunosorbent assay （ELISA）. The relationship between the plasma thrombomodulin level and severity of coronary arterial lesion was observed. Results The plasma thrombomodulin concentrations of instable angina pectoris group were significantly higher than those of stable angina pectoris group, their levels of myocardial infarction group were higher than those of instable angina pectoris group. Conclusions Higher level of the plasma thrombomodulin is associated with increased severity of coronary arterial lesion in T2DM. It suggests that serum concentrations of the plasma thrombomodulin can be a parameter for predicting the severity of coronary arterial lesion in T2DM.