三种药物促进宫颈成熟的临床应用观察

The clinical application observation of three drugs to promote cervical ripening

目的 观察普贝生、米索前列醇、缩宫素三种促进宫颈成熟药物的有效性和安全性。方法采用随机对照研究方法，将180例初产妇分为3组，A组：普贝生；B组：小剂量米索前列醇组；C组：缩宫素组。比较三组用药前、后4、8、12h宫颈Bishop评分，用药后分娩情况、胎儿窘迫及新生儿窒息的发生率。结果A、B、C三组的有效率分别为88．3％、85．0％、35．0％；用药后剖宫产率分别为21．7％、25．0％、60．0％。A，B组分别与C组比较差异有统计学意义（P〈0．05）。结论普贝生及米索前列醇均是安全、有效的，临床应用成功率高；缩宫素则疗效欠佳。

Objective To observe the efficacy and safety of three drugs（dinoprostone suppositories, misoprostol and oxytocin）to promote cervical ripening. Methods A randomized control study method was used. The180 primipara was divided into 3 groups. Group A ： dinoprostone suppositories, Group B ： low-dose misoprostol, Group C：oxytocin. The maternal cervical Bishop score of three drugs being used before and after 4,8,12 h was compared between the three groups, as well as the labor situation, the rate of fetal distress and neonatal asphyxia after the drugs. Results The effective rates of groups A,B,C were 88.3% ,85. 0% ,35. 0%. The cesarean section rates of three groups were 21.7% ,25. 0% ,60. 0%. There was significantly different between groups A, B with group C （P 〈 0.05 ）. Conclusion Dinoprostone suppositories and misoprostol were safe and effective, and they had a high success rate of clinical application. Then Oxytocin was iU effect.